Does typical confluent drusen confer a greater risk of AMD?

Typical confluent drusen are deposits that can accumulate in the retina and are associated with age-related macular degeneration (AMD). The presence of these drusen, particularly when they are soft and larger, is indeed correlated with an increased risk of developing advanced AMD. Soft drusen are considered more pathological than hard drusen, as they are often associated with more significant retinal pigmentary changes and choroidal neovascularization, both of which are critical features that can lead to vision loss in AMD.

The link between confluent drusen and the progression of AMD is well-observed in clinical practice and research. These drusen can indicate a more severe underlying pathological process, contributing to the deterioration of retinal health and increasing the likelihood of complications associated with AMD. Understanding the characteristics of drusen helps in identifying patients who may need closer monitoring and potential intervention to manage their risk of visual impairment effectively.