GA can result from areas of reabsorbed drusen and what other condition?

Geographic atrophy (GA) is often associated with the atrophy of retinal pigmented epithelium, which can indeed result from the reabsorption of drusen. In the context of age-related macular degeneration (AMD), when drusen are reabsorbed, it can lead to the condition known as GA. Pigment epithelial detachments (PEDs) are localized elevations of the retinal pigment epithelium that can also play a role in the development of GA. When these detachments occur, they can cause damage to the retinal structure, leading to the progressive loss of retinal pigment epithelium and ultimately contributing to the development of geographic atrophy.

The interplay between reabsorbed drusen and pigment epithelial detachments highlights a pathway in AMD progression, where the structural integrity of the retinal pigment epithelium is compromised. This is integral for maintaining photoreceptor health, and its demise can lead to GA, reflecting the degenerative changes associated with advancing age-related macular degeneration.