How are serous PEDs characterized on fundus autofluorescence (FAF)?

Serous pigment epithelial detachments (PEDs) are characterized by areas of hyperautofluorescence on fundus autofluorescence (FAF). This hyperautofluorescence occurs due to the accumulation of fluid underneath the retinal pigment epithelium, which alters the normal fluorescence pattern. The presence of the serous fluid leads to a disruption in the retinal pigment epithelium’s function, resulting in an increased signal on FAF. The fluid essentially traps fluorescence emitting substances, leading to the observed hyperautofluorescent appearance.

By understanding this characteristic, clinicians can utilize FAF as a key imaging modality to assess PEDs and their underlying causes, facilitating better diagnosis and management of conditions like age-related macular degeneration (AMD) and other causes of choroidal neovascularization (CNV).