How do fibrovascular pigment epithelial detachments (PEDs) typically respond to therapy?

Fibrovascular pigment epithelial detachments (PEDs) are associated with various retinal conditions, particularly age-related macular degeneration (AMD). These detachments typically pose a challenge in terms of treatment response. They are frequently resistant to standard therapies such as anti-VEGF injections, which are more effective for other types of choroidal neovascularization (CNV) but may not address the underlying issues caused by the fibrovascular element in these PEDs.

As a result, patients with fibrovascular PEDs often experience significant visual acuity loss. This is due to the persistent nature of the PEDs and their ability to disrupt the normal retinal architecture and function. These detachments can also contribute to ongoing retinal damage and scarring, which complicates treatment outcomes. Therefore, the overall prognosis for visual acuity in patients with fibrovascular PEDs tends to be poor, confirming that they indeed resist therapy and can lead to substantive visual degeneration.