In the context of dry AMD, the highest GA progression rates were observed in which pattern?

In the context of dry age-related macular degeneration (AMD), the highest geographic atrophy (GA) progression rates are observed in the diffuse pattern. Diffuse geographic atrophy is characterized by a more widespread presence of atrophy within the retinal pigment epithelium (RPE) and can lead to more extensive loss of photoreceptors and associated retinal structures. This pattern is particularly concerning as it correlates with a more rapid and severe decline in visual function compared to other patterns, such as focal or reticular.

The diffuse pattern indicates a more uniform, expansive area of GA, which facilitates continuous progression over time. In contrast, focal patterns might exhibit localized areas of atrophy and typically progress at a slower rate due to their limited extent. On the other hand, the reticular pattern presents a grid-like appearance with patches of atrophy but does not progress as aggressively as the diffuse pattern. Understanding these progression rates is crucial for monitoring and managing patients with dry AMD effectively.