Is the vitreous involved in ocular histoplasmosis syndrome (OHS)?

The involvement of the vitreous in ocular histoplasmosis syndrome (OHS) is generally not significant, making the response that states "no" accurate. In OHS, the primary effects are on the retina, particularly causing choroidal neovascularization, which can lead to complications such as macular scarring and vision impairment. The primary inflammatory response occurs in the retinal and choroidal layers rather than extending into the vitreous body.

While there might be secondary effects, such as the presence of vitreous opacities in certain scenarios, the initial pathophysiological process associated with histoplasmosis predominantly targets the retinal structures. This distinction helps clarify why involvement of the vitreous is not a defining aspect of the syndrome in the majority of cases.

Therefore, saying that the vitreous is not involved reflects an understanding of the typical clinical presentation of OHS, focusing on how the disease manifests primarily in retinal layers without significant direct impact on the vitreous itself.