Occult CNV occurs at which anatomical location?

Occult choroidal neovascularization (CNV) is characterized by the growth of new blood vessels that can penetrate the retinal layers but do so in a manner that is not easily observed through standard imaging techniques. The correct anatomical location for occult CNV is above Bruch's membrane but below the retinal pigment epithelium (RPE).

In this context, Bruch's membrane serves as a barrier, and when neovascularization occurs above this membrane, it indicates that the new blood vessels are situated in the subretinal space, which is the area just below the RPE. This location is significant because the occult nature of the CNV implies that it doesn't present with the typical clinical signs associated with more severe forms of CNV. Rather, it can exist quietly, often leading to vision changes that are subtle and difficult to detect initially.

The association with the RPE is crucial since this layer is vital for various retinal functions, including supporting photoreceptors and participating in the visual cycle. Thus, the correct answer highlights the specific positioning of occult CNV relative to these structures and explains the challenges in visualizing them, particularly via imaging modalities such as fluorescein angiography, where these vessels may not leak visible dye compared to