On fluorescein angiography (FA), how do serous PEDs typically present?

Serous pigment epithelial detachments (PEDs) typically exhibit early hyperfluorescence with gradual pooling on fluorescein angiography. This characteristic presentation occurs because serous PEDs are associated with subretinal fluid accumulation, which allows for increased permeability of the retinal pigment epithelium (RPE). Initially, the area appears hyperfluorescent due to the leakage of fluorescein into the subretinal space. Over time, the amassed fluid causes further accumulation, leading to a gradual pooling effect. This accumulation can be seen as a pronounced area of fluorescence that becomes more prominent throughout the angiography procedure.

The other options do not align with the typical imaging characteristics of serous PEDs. For instance, late leakage and pooling would be more relevant in conditions where there is a significant breakdown of the blood-retinal barrier. Initial hypo-fluorescence might occur in other types of lesions, often due to blockage or an absence of fluorescence leakage. Uniform opacity does not accurately describe the dynamic nature of serous PEDs, which are characterized by changes in fluorescence as the fluorescein interacts with the accumulated fluid. Thus, the correct choice highlights the distinctive presentation of serous PEDs during fluorescein angiography, emphasizing the early hyper