On ICGA, how do Fibrovascular PEDs typically appear?

Fibrovascular pigment epithelial detachments (PEDs) are typically characterized on Indocyanine Green Angiography (ICGA) by a focal hyper-fluorescent area. This hyper-fluorescence occurs due to the presence of vascular components within the fibrovascular PEDs, which actively leak Indocyanine Green dye. This contrasts with other types of PEDs, which may display different fluorescence patterns.

Focal hyper-fluorescence is indicative of the neovascularization associated with these lesions, highlighting the extent of the underlying pathology. The distinct pattern helps in the differentiation of fibrovascular PEDs from other conditions that may present similarly, allowing for a more accurate diagnosis and management strategy in patients with age-related macular degeneration (AMD) and other causes of choroidal neovascularization (CNV).