Reticular pseudodrusen (RPD) contribute to which type of retinal atrophy?

Reticular pseudodrusen (RPD) are a specific type of retinal finding associated with age-related macular degeneration (AMD) and are noted for their relationship with geographic atrophy (GA). Geographic atrophy refers to a pattern of retinal degeneration characterized by the localized loss of retinal pigment epithelium (RPE) and photoreceptors, leading to well-defined areas of atrophy.

RPD typically appear as a network-like pattern on imaging and are believed to be associated with an underlying pathology that can progress to geographic atrophy. The presence of RPD has been shown to increase the risk of developing GA by contributing to the degenerative changes in the macular area. This connection highlights the importance of recognizing RPD as a risk factor for the progression of AMD to a more severe form characterized by geographic atrophy.

While other forms of atrophy, such as macular atrophy or focal atrophy, may occur, these are not the primary associations of RPD. Understanding the link between RPD and geographic atrophy is crucial for recognizing the potential progression of AMD and implementing appropriate monitoring or therapeutic strategies.