The presence of a diffuse trickling pattern is primarily linked to what aspect of GA?

The presence of a diffuse trickling pattern in geographic atrophy (GA) is primarily linked to a high risk of progression. This pattern indicates a more widespread and ongoing degeneration of retinal pigment epithelium (RPE) cells, which is associated with a more aggressive course of the disease. When the trickling diffusion occurs, it suggests that the areas of atrophy are continuing to spread rather than remaining stable, which ultimately increases the likelihood of further visual loss and progression of GA. Understanding this aspect is crucial, as it can influence monitoring and management strategies in patients, highlighting the need for closer surveillance and potentially more aggressive intervention in cases exhibiting this pattern.