What are the extracellular protein deposits found at the interface of RPE and Bruch's membrane called?

The extracellular protein deposits located at the interface of the retinal pigment epithelium (RPE) and Bruch's membrane are termed drusen. These deposits are typically composed of a mixture of lipids, proteins, and other cellular debris and are most commonly associated with age-related macular degeneration (AMD).

Drusen can vary in size and, in many cases, their presence is an indication of underlying retinal health issues, serving as a key factor in the progression of AMD. The development of drusen is believed to be a part of the aging process and represents a disruption in the normal functioning of the RPE and Bruch's membrane. Understanding the role of drusen is crucial in assessing the risk and progression of macular diseases, making them a significant subject of study in ophthalmology.

In contrast, the other options do not accurately refer to these specific deposits or lack the clinical significance and recognized definition associated with drusen in the context of retinal diseases.