What association exists between the size of Geographic Atrophy lesions and progression rate?

The understanding of Geographic Atrophy (GA) in the context of age-related macular degeneration (AMD) highlights the relationship between lesion size and disease progression. Research has shown that larger Geographic Atrophy lesions tend to correlate with faster progression and worsening visual outcomes. Smaller lesions, on the other hand, generally indicate a more stable condition that may not deteriorate as rapidly. This relationship suggests that when lesions are smaller, the rate of progression is actually lower compared to when larger lesions are present. Hence, smaller Geographic Atrophy lesions are associated with less aggressive progression of the disease, supporting the choice that smaller lesions correlate with lower progression rates. This concept underscores the importance of monitoring lesion size in patients with AMD, as it can provide valuable insights into the potential course of the disease.