What causes choroidal rupture in the context of neovascular AMD?

Choroidal rupture is a structural break in the choroid layer of the eye, and its occurrence in the context of neovascular age-related macular degeneration (AMD) is primarily due to direct trauma or shearing forces. In neovascular AMD, the development of abnormal blood vessels under the retina can create significant tension and stress on the underlying structures. This mechanical strain can lead to tears or ruptures in the choroid as the abnormal vessels proliferate and cause deformation of the retinal layers.

While other factors such as genetic predispositions, systemic hypertension, and chronic inflammation can play roles in the overall pathology of neovascular AMD, they do not directly cause choroidal rupture. Instead, it is the physical forces exerted by the pathological changes in the eye that are responsible for this specific complication. Understanding this connection highlights the mechanical aspects of how neovascular processes impact the structural integrity of choroidal tissues in AMD.