What characterizes AREDS Intermediate AMD grading stage?

AREDS Intermediate AMD grading stage is characterized by the presence of numerous intermediate drusen, which are defined as drusen that are larger than small drusen but smaller than large drusen. This stage indicates a progression of age-related macular degeneration (AMD) where the accumulation of drusen is significant enough to increase the risk of vision loss compared to earlier stages with only small drusen present.

The presence of numerous intermediate drusen suggests a higher likelihood of developing advanced AMD, as drusen are associated with the degeneration of retinal structures. Furthermore, the absence of advanced features such as geographic atrophy or choroidal neovascularization is critical in defining the intermediate stage, making the presence of numerous intermediate drusen the hallmark characteristic distinguishing it from other stages of AMD.