What condition is directly associated with areas of reabsorbed drusen in Geographic Atrophy?

Geographic Atrophy (GA) is a result of retinal degeneration that primarily involves the retinal pigment epithelium (RPE) and photoreceptors. The presence of areas of reabsorbed drusen is closely linked to the dysfunction of the RPE. Drusen are subretinal deposits that appear as yellow-white lesions and are commonly associated with age-related macular degeneration (AMD). When drusen undergo reabsorption, it often indicates a progressive deterioration of the RPE, which leads to the loss of overlying photoreceptors and the characteristic atrophic changes seen in GA.

In this context, the dysfunction of the RPE plays a pivotal role in the development of geographic atrophy, as the RPE is responsible for various critical functions including the support of photoreceptors, the phagocytosis of shed photoreceptor outer segments, and the maintenance of the blood-retinal barrier. When the RPE is impaired, as evidenced by the observed reabsorption of drusen, it contributes significantly to the pathology of GA. The condition reflects a direct association, making it the most relevant answer in this scenario.