What does the detachment in PED occur between?

In the context of the pathophysiology of age-related macular degeneration (AMD) and particularly pigment epithelium detachment (PED), the detachment occurs between the retinal pigment epithelium (RPE) and the internal limiting collagenous layer of Bruch's membrane. This relationship is critical because Bruch's membrane serves as a structural support for the RPE and plays a significant role in the transport of nutrients and waste between the choroid and the retina.

When PED occurs, it typically indicates an abnormal accumulation of fluid or material that separates the RPE from Bruch's membrane. This can lead to functional impairment of the RPE, which is vital for maintaining photoreceptor health and function. Understanding the location and mechanism of such detachments is essential for diagnosing and managing conditions like AMD.

The other choices provided do not correctly identify the specific relationship involved in PED. The detachment cannot occur between RPE and the choriocapillaris, the inner retinal layer and RPE, or Bruch's membrane and the photoreceptor layer in the context of PED; these layers are structurally distinct and involve different pathological processes.