What is a common characteristic for patients with pseudoxanthoma elasticum?

Pseudoxanthoma elasticum (PXE) is a genetic disorder that affects the connective tissues of the body, particularly the elastic fibers. A common characteristic of patients with this condition is indeed the presence of a combination of features that can include reduced life expectancy, cardiovascular complications, and variable skin manifestations.

The variable skin manifestations often include yellowish papules and changes in skin texture, which are prominent in individuals with PXE. These skin changes can vary significantly from one patient to another, making them a clear characteristic of the condition.

Patients with PXE are also at an increased risk for cardiovascular complications. This can include issues such as vascular calcification, which may lead to serious cardiovascular events. The potential for these complications contributes to the overall reduction in life expectancy observed in some individuals with PXE, particularly due to the associated risks of cardiovascular disease.

Since all these characteristics—reduced life expectancy, cardiovascular complications, and variable skin manifestations—are prevalent in patients with pseudoxanthoma elasticum, the choice that includes all of the above accurately captures the multifaceted impact of this disorder.