What is indicated by abnormal junctional zone features on OCT in terms of progression?

Abnormal junctional zone features observed on OCT (Optical Coherence Tomography) indicate a faster progression of certain retinal conditions, particularly those related to choroidal neovascularization (CNV). The junctional zone is the area where the retinal pigment epithelium (RPE) meets the outer segments of photoreceptors, and changes in this area can signify alterations in the underlying choroidal structure or the health of the retina.

When there are abnormalities in this zone, it may reflect an active pathological process, such as inflammation or neovascularization associated with conditions like age-related macular degeneration (AMD). These changes can often correlate with an increased risk for deterioration in visual function and an escalation in disease severity.

In contrast, junctional zone features that are normal typically suggest a more stable situation with potentially slower progression of the underlying condition. Therefore, understanding these features on OCT is crucial for predicting the clinical course in patients with CNV and for guiding treatment strategies.