What is the definition of angiogenesis?

Angiogenesis refers to the process through which new blood vessels form from pre-existing ones. This biological event is crucial for various physiological and pathological processes, including wound healing, tissue regeneration, and growth of tumors. During angiogenesis, endothelial cells, which line blood vessels, proliferate and migrate to create new vascular structures, facilitating increased blood flow and nutrient supply to tissues.

In contrast, the other concepts mentioned do not accurately define angiogenesis. The inhibition of blood vessel growth refers to anti-angiogenic processes, while the destruction of existing blood vessels relates to vessel regression or atrophy. The maintenance of blood vessel health involves the regulation of existing vessels but does not encompass the creation of new ones. Thus, the definition of angiogenesis is central to understanding conditions such as age-related macular degeneration and other diseases characterized by aberrant blood vessel growth.