What is the expected size of large drusen compared to intermediate drusen?

Large drusen are defined as having a diameter greater than 125 micrometers. This size classification differentiates them from intermediate drusen, which generally range between 63 and 125 micrometers in diameter. The distinction in size is clinically significant as it relates to the risk of progression to advanced age-related macular degeneration (AMD).

Large drusen are considered a risk factor for developing changes associated with AMD, including choroidal neovascularization (CNV), which can lead to vision loss. Understanding the size of drusen is crucial in ophthalmology to assess the potential for vision impairment and to guide monitoring strategies for patients at risk for AMD. Thus, recognizing that large drusen exceed 125 micrometers solidifies their classification and significance in retinal health assessments.