What is the recommended daily supplementation of Vitamin E based on AREDS2?

The recommended daily supplementation of Vitamin E based on the Age-Related Eye Disease Study 2 (AREDS2) is 400 IU. This study focused on the effects of various supplements on the progression of age-related macular degeneration (AMD) and found that this dose of Vitamin E plays a crucial role in reducing the risk of advanced AMD and vision loss. The formulation used in AREDS2 aimed to optimize the balance of antioxidants to support eye health while minimizing potential risks. The decision to settle on 400 IU was based on clinical evidence that suggested it was effective without any associated negative outcomes at that dosage. Thus, Vitamin E at this specific dosage is considered beneficial in the context of AMD management according to the findings of the study.