What is the role of photodynamic therapy in AMD treatment?

Photodynamic therapy (PDT) plays a significant role in the treatment of age-related macular degeneration (AMD) by specifically targeting and destroying abnormal blood vessels that contribute to choroidal neovascularization (CNV). In cases of wet AMD, abnormal blood vessels grow under the retina and can leak fluid or bleed, leading to vision loss.

PDT utilizes a light-sensitive drug that is injected into the bloodstream, and when activated by a specific wavelength of light, it generates reactive oxygen species that selectively destroy these abnormal blood vessels while sparing surrounding healthy tissue. This targeted approach helps to stabilize or improve vision by addressing one of the key pathological processes associated with wet AMD.

While improving visual acuity, regenerating photoreceptors, or enhancing retinal pigment epithelium function are important aspects of eye health, these are not the primary functions of photodynamic therapy in the context of AMD treatment. The main focus of PDT is specifically on eliminating the damaging neovascular components, which makes it a critical intervention for managing this condition.