What separation facilitates drug penetration, requiring fewer injections?

The separation that facilitates drug penetration, requiring fewer injections, is the hyaloidal separation. This occurs in the context of drug delivery to the posterior segment of the eye. The hyaloid membrane, which is part of the vitreous humor, can form a barrier that limits direct access to the underlying retina and choroid. However, when separation occurs between the hyaloid membrane and the retina, it allows for enhanced absorption and distribution of drug formulations within the vitreous cavity.

In situations of hyaloidal separation, the volume of the drug can diffuse more effectively toward the retina and the underlying tissues, leading to a therapeutic effect with reduced frequency of injections. By minimizing the number of injections required, this approach not only enhances patient comfort but can also improve compliance with treatment regimens.

In contrast, the retinal, choroidal, and ciliary layers do not facilitate the same degree of enhancement in drug penetration as the hyaloidal separation. Each of these layers has its own anatomical and physiological characteristics that do not support the same level of access for drug delivery, making hyaloidal separation particularly advantageous in the context of treating conditions such as age-related macular degeneration (AMD) and other diseases associated with choroidal neovascularization (CN