What systemic disease is most commonly linked to angioid streaks?

Angioid streaks are often associated with pseudoxanthoma elasticum (PXE) because this condition involves a genetic mutation that affects the elastic fibers in connective tissue. As a result of this condition, there is a progressive calcification and fragmentation of the elastic laminae in various tissues, including the Bruch's membrane of the eye. This leads to the formation of angioid streaks, which are lines that appear in the retina due to breaks in Bruch's membrane.

While other systemic diseases have their own ocular manifestations, the relationship between angioid streaks and PXE is particularly strong and well-documented. PXE can lead to various complications, such as choroidal neovascularization and vision loss, making it significant for both general health and ophthalmic considerations. Recognizing this association is critical for proper diagnosis and management of patients who present with angioid streaks.