Where are basal laminar deposits found?

Basal laminar deposits are typically found both external to the retinal pigment epithelium (RPE) plasma membrane and internal to the RPE basement membrane. These deposits are associated with the pathophysiology of age-related macular degeneration (AMD) and represent one of the characteristic findings in conditions involving the RPE.

In the context of AMD, basal laminar deposits can form as a consequence of the accumulation of lipids and other materials that are not adequately cleared by the RPE. This accumulation can disrupt normal RPE function and contribute to the development of choroidal neovascularization (CNV), a key feature of advanced AMD.

Understanding the location of these deposits is crucial for recognizing their role in retinal pathologies. They signify changes that occur at the retinal level, especially relating to the RPE’s health and the surrounding retinal structures. The presence of basal laminar deposits contributes to our understanding of the progression of AMD and highlights the importance of monitoring these findings in patients.