Where are Reticular pseudodrusen (RPD) predominantly located?

Reticular pseudodrusen (RPD) are predominantly located above the retinal pigment epithelium (RPE). This positioning is significant because it relates to the pathophysiology of age-related macular degeneration (AMD) and the associated choroidal neovascularization (CNV).

RPD are typically observed as a distinct type of drusen and are identified by their reticular, lace-like pattern, which can be seen through imaging techniques such as optical coherence tomography (OCT). Their presence in the subretinal space, specifically above the RPE, suggests that they are formed by the accumulation of material in the layers just beneath the neurosensory retina, indicating a disruption in the normal retinal architecture and potential consequences for visual function.

Recognizing the correct location of RPD is crucial for understanding their relationship with AMD and other retinal diseases, as their presence can denote a higher risk for progression to advanced stages of the disease and complications such as CNV. Thus, knowing that RPD are situated above the RPE helps clinicians assess the condition of the retina more effectively and determine appropriate monitoring and treatment strategies.