Where does an occult CNV lesion typically occur?

An occult choroidal neovascularization (CNV) lesion typically occurs in the sub-retinal pigment epithelium (sub-RPE) space. This localization is significant because it often represents a more subtle form of neovascularization that may not be readily visible on traditional imaging modalities. Unlike classic CNV, which tends to present more aggressively in the subretinal space, an occult lesion forms beneath the RPE, leading to a less pronounced or hidden clinical presentation.

Detecting sub-RPE CNV can be challenging, as it can be more associated with conditions like age-related macular degeneration (AMD). The detection may rely on advanced imaging techniques such as optical coherence tomography (OCT) that can reveal the characteristics of these lesions. Understanding where occult CNV typically occurs is crucial for diagnosis and treatment planning, allowing for appropriate management of potential vision loss associated with these conditions.