Which antioxidant is part of the AREDS1 regimen noted to prevent zinc-induced anemia?

The correct answer relates to the inclusion of Vitamin C in the AREDS1 (Age-Related Eye Disease Study) regimen, which was designed to evaluate the effects of various antioxidants and zinc on the progression of age-related macular degeneration (AMD). Vitamin C plays a crucial role in the body's antioxidant defense system, helping to neutralize free radicals and protect against oxidative stress that can lead to cellular damage. This is particularly relevant in the context of zinc, as high doses of zinc can sometimes lead to deficiencies in copper, and accordingly, vitamin C is thought to contribute to the maintenance of overall health and deter potential deficiencies induced by zinc supplementation.

By supporting the integrity of copper metabolism, Vitamin C helps to mitigate the risk of zinc-induced anemia, which can occur due to a disruption in the balance of trace metals in the body. The inclusion of Vitamin C in the regimen, therefore, not only promotes ocular health but also plays a role in preventing adverse effects associated with zinc supplementation.