Which conditions would prompt consideration for antioxidant supplementation?

The consideration for antioxidant supplementation, particularly in the context of age-related macular degeneration (AMD), is strongly associated with the presence of extensive intermediate drusen. These drusen indicate a higher risk for progression to advanced forms of AMD. Antioxidants, such as those found in the AREDS (Age-Related Eye Disease Study) formulation, have been shown to reduce the risk of developing advanced AMD in patients with these specific retinal findings.

Patients with one large drusen may still be at risk, but the evidence supporting supplementation is primarily focused on those exhibiting extensive intermediate drusen. Healthy vision usually does not warrant the need for supplements since there is no significant risk of progression. Similarly, age-related dry eye syndrome is not directly linked to the effects of AMD and would not trigger the same considerations for antioxidant supplementation. Hence, the presence of extensive intermediate drusen stands out as a key indicator for the use of these supplements in AMD management.