Which of the following is a significant risk factor for AMD?

A positive family history is a significant risk factor for Age-related Macular Degeneration (AMD) because genetic predisposition plays a critical role in the development of the disease. Individuals with relatives who have AMD are more likely to develop the condition themselves, suggesting a hereditary component. Genetic studies have identified several risk alleles associated with AMD, indicating that a family history can be a strong pointer towards individual susceptibility.

In contrast, low blood pressure and high levels of exercise have not been established as direct risk factors for AMD. While they might contribute to overall cardiovascular health, this does not correlate with an increased risk for AMD. Youthful age is also not considered a risk factor; in fact, AMD typically occurs in older adults, making age a significant risk factor rather than youth. Understanding these nuances is essential for recognizing risk factors associated with AMD.