Which type of abnormal blood vessel proliferation is primarily associated with AMD?

Choroidal Neovascularization (CNV) is the type of abnormal blood vessel proliferation that is primarily associated with Age-related Macular Degeneration (AMD). In AMD, particularly in its wet form, new blood vessels develop in the choroid layer beneath the retina and can invade the retinal pigment epithelium and the subretinal space. This abnormal growth occurs due to breakdown of the blood-retinal barrier and is driven by factors such as vascular endothelial growth factor (VEGF). The presence of these newly formed vessels can lead to further complications, including retinal detachment and significant vision impairment due to leakage of fluid or blood.

Other options, while related to various ocular conditions, do not specifically correlate with the typical progression and pathology associated with AMD. Retinal Neovascularization, for example, is more commonly associated with conditions like diabetic retinopathy. Foveal Avascular Zone Expansion pertains to alterations in the central retina's structure, and Subretinal Hemorrhage may occur due to CNV but is not itself a type of blood vessel proliferation. Thus, Choroidal Neovascularization is the hallmark of AMD's neovascular pathophysiology.